A Randomized Controlled Trial Comparing two Cognitive-Behavioral Programs for Adolescent Girls with Subclinical Depression: A School-Based Program (Op Volle Kracht) and a Computerized Program (SPARX)

Limited research has indicated the effectiveness of the school-based Cognitive Behavioral Therapy (CBT) prevention program ‘Op Volle Kracht (OVK)’ and the computerized CBT program ‘SPARX’ in decreasing depressive symptoms. Therefore, a randomized controlled trial of the effectiveness of OVK and SPARX was conducted among Dutch female adolescents (n = 208, mean age = 13.35) with elevated depressive symptoms. Participants were randomly assigned to one of four conditions: OVK only (n = 50), SPARX only (n = 51), OVK and SPARX combined (n = 56) and a monitoring control condition (n = 51). Participants in the first three conditions received OVK lessons and/or the SPARX game. Depressive symptoms were assessed before interventions started, weekly during the interventions, and immediately after the interventions ended, with follow-up assessments at 3, 6 and 12 months. Intention to treat results showed that depressive symptoms decreased in all conditions (F(12, 1853.03) = 14.62, p < .001), with no difference in depressive symptoms between conditions. Thus, all conditions, including the monitoring control condition, were equally effective in reducing depressive symptoms. Possible explanations for the decrease of depressive symptoms in all conditions are discussed and suggestions for future research are provided. Dutch Trial Register: NTR3737

Modeling Ultraviolet Wind Line Variability in Massive Hot Stars

We model the detailed time-evolution of Discrete Absorption Components (DACs) observed in P Cygni profiles of the Si IV lam1400 resonance doublet lines of the fast-rotating supergiant HD 64760 (B0.5 Ib). We adopt the common assumption that the DACs are caused by Co-rotating Interaction Regions (CIRs) in the stellar wind. We perform 3D radiative transfer calculations with hydrodynamic models of the stellar wind that incorporate these large-scale density- and velocity-structures. We develop the 3D transfer code Wind3D to investigate the physical properties of CIRs with detailed fits to the DAC shape and morphology. The CIRs are caused by irregularities on the stellar surface that change the radiative force in the stellar wind. In our hydrodynamic model we approximate these irregularities by circular symmetric spots on the stellar surface. We use the Zeus3D code to model the stellar wind and the CIRs, limited to the equatorial plane. We constrain the properties of large-scale wind structures with detailed fits to DACs observed in HD 64760. A model with two spots of unequal brightness and size on opposite sides of the equator, with opening angles of 20 +/- 5 degr and 30 +/- 5 degr diameter, and that are 20 +/- 5 % and 8 +/- 5 % brighter than the stellar surface, respectively, provides the best fit to the observed DACs. The recurrence time of the DACs compared to the estimated rotational period corresponds to spot velocities that are 5 times slower than the rotational velocity. The mass-loss rate of the structured wind model for HD 64760 does not exceed the rate of the spherically symmetric smooth wind model by more than 1 %. The fact that DACs are observed in a large number of hot stars constrains the clumping that can be present in their winds, as substantial amounts of clumping would tend to destroy the CIRs.Comment: 58 pages, 16 figures, 1 animation. Accepted for publication in The Astrophysical Journal, Main Journal. More information and animations are available at http://alobel.freeshell.org/hotstars.htm

On the CO Near-Infrared Band and the Line-splitting Phenomenon in the Yellow Hypergiant ρ Cassiopeiae

We report on multiepoch optical and near-infrared spectroscopy around the first-overtone rovibrational band of CO in the pulsating yellow hypergiant ρ Cas, one of the most massive stars in the Galaxy and a candidate SN II progenitor. We argue that the double cores of the CO absorption lines, which have previously been attributed to separate circumstellar shells expelled during its recurrent outbursts, result in fact from a superposition of a wide absorption line and a narrow central emission line. The CO line doubling returns over subsequent pulsation cycles, where the superposed line emission assumes its largest intensity near phases of maximum light. We find that the morphology and behavior of the CO band closely resemble the remarkable "line-splitting phenomenon" also observed in optical low-excitation atomic lines. Based on radiative transport calculations, we present a simplified model of the near-infrared CO emission emerging from cooler atmospheric layers in the immediate vicinity of the photosphere. We speculate that the kinetic temperature minimum in our model results from a periodic pulsation-driven shock wave. We further discuss a number of alternative explanations for the origin of the ubiquitous emission-line spectrum, possibly due to a quasi-chromosphere or a steady shock wave at the interface of a fast expanding wind and the interstellar medium. We present a number of interesting spectroscopic similarities between ρ Cas and other types of cool variable supergiants, such as the RV Tau and R CrB stars. We further propose a possibly common mechanism for the enigmatic outburst behavior of these luminous pulsating cool stars

On the CO Near-IR Band and the Line Splitting Phenomenon in the Yellow Hypergiant Rho Cassiopeiae

We report on multi-epoch optical and near-infrared spectroscopy around the first overtone ro-vibrational band of CO in the pulsating yellow hypergiant Rho Cas, one of the most massive stars in the Galaxy and a candidate SN II progenitor. We argue that the double cores of the CO absorption lines, that have previously been attributed to separate circumstellar shells expelled during its recurrent outbursts, result in fact from a superposition of a wide absorption line and a narrow central emission line. The CO line doubling returns over subsequent pulsation cycles, where the superposed line emission assumes its largest intensity near phases of maximum light. We find that the morphology and behavior of the CO band closely resemble the remarkable "line-splitting phenomenon" also observed in optical low-excitation atomic lines. Based on radiative transport calculations we present a simplified model of the near-IR CO emission emerging from cooler atmospheric layers in the immediate vicinity of the photosphere. We speculate that the kinetic temperature minimum in our model results from a periodical pulsation-driven shock wave. We further discuss a number of alternative explanations for the origin of the ubiquitous emission line spectrum, possibly due to a quasi-chromosphere or a steady shock wave at the interface of a fast expanding wind and the ISM. We present a number of interesting spectroscopic similarities between Rho Cas and other types of cool variable supergiants such as the RV Tau and R CrB stars. We further propose a possibly common mechanism for the enigmatic outburst behavior of these luminous pulsating cool stars.Comment: accepted to ApJ; 3 color fig

FAM-MDR: A Flexible Family-Based Multifactor Dimensionality Reduction Technique to Detect Epistasis Using Related Individuals

We propose a novel multifactor dimensionality reduction method for epistasis detection in small or extended pedigrees, FAM-MDR. It combines features of the Genome-wide Rapid Association using Mixed Model And Regression approach (GRAMMAR) with Model-Based MDR (MB-MDR). We focus on continuous traits, although the method is general and can be used for outcomes of any type, including binary and censored traits. When comparing FAM-MDR with Pedigree-based Generalized MDR (PGMDR), which is a generalization of Multifactor Dimensionality Reduction (MDR) to continuous traits and related individuals, FAM-MDR was found to outperform PGMDR in terms of power, in most of the considered simulated scenarios. Additional simulations revealed that PGMDR does not appropriately deal with multiple testing and consequently gives rise to overly optimistic results. FAM-MDR adequately deals with multiple testing in epistasis screens and is in contrast rather conservative, by construction. Furthermore, simulations show that correcting for lower order (main) effects is of utmost importance when claiming epistasis. As Type 2 Diabetes Mellitus (T2DM) is a complex phenotype likely influenced by gene-gene interactions, we applied FAM-MDR to examine data on glucose area-under-the-curve (GAUC), an endophenotype of T2DM for which multiple independent genetic associations have been observed, in the Amish Family Diabetes Study (AFDS). This application reveals that FAM-MDR makes more efficient use of the available data than PGMDR and can deal with multi-generational pedigrees more easily. In conclusion, we have validated FAM-MDR and compared it to PGMDR, the current state-of-the-art MDR method for family data, using both simulations and a practical dataset. FAM-MDR is found to outperform PGMDR in that it handles the multiple testing issue more correctly, has increased power, and efficiently uses all available information

Micro-Symposium on Orin Kerr\u27s \u27A Theory of Law\u27

For more than a century, careful readers of the Green Bag have known that “[t]here is nothing sacred in a theory of law...which has outlived its usefulness or which was radically wrong from the beginning...The question is What is the law and what is the true public policy?” Professor Orin Kerr bravely, creatively, and eloquently answered that question in his article, “A Theory of Law,” in the Autumn 2012 issue of the Green Bag. Uniquely among all theories of law that I know of, Kerr’s answer to the fundamental question of law and true public policy enables all scholars to answer that same question in their own ways. The Green Bag is pleased to be featuring his “A Theory of Law” in its first micro-symposium, and just as pleased with the quality, quantity, and diversity of the responses to the call for papers. Blessed with an abundance of good work but cursed by a shortage of space, we were compelled to select a small set – representative and excellent – of those essays to publish in the Green Bag or its sibling publication, the Journal of Law. We regret that we cannot do full justice to the outpouring of first-rate legal-theoretical commentary we received

The benefit of sequentiality in social networks *

Abstract This paper examines the benefit of sequentiality in the social networks. We adopt the elegant theoretical framework proposed by We then examine the structure of optimal mechanism and allow for arbitrary sequence of players&apos; moves. We show that starting from any fixed sequence, the aggregate contribution always goes up while making simultaneous-moving players move sequentially. This suggests a robust rule of thumbs -any local modification towards the sequential-move game is beneficial. Pushing this idea to the extreme, the optimal sequence turns out to be a chain structure, i.e., players should move one by one. Our results continue to hold when either players exhibit strategic substitutes instead or the network designer&apos;s goal is to maximize the players&apos; aggregate payoff rather than the aggregate contribution

High-quality habitat and facilitation ameliorate competitive effects of prior residents on new settlers

Many species disperse during their lifetime. Two factors that can affect the performance of individuals following dispersal are the presence of conspecifics and intrinsic habitat quality at the settlement site. Detecting the influence of these factors can be difficult for at least two reasons: (1) the outcomes of interactions with conspecifics are often variable including both competition and facilitation, and (2) selection of high quality habitats often leads to positive covariance between habitat quality and density. In this study, I investigate positive and negative effects of resident blue streak cleaner wrasse (Labroides dimidiatus) on the growth and survival of recently settled conspecifics while accounting for habitat quality. Juvenile L. dimidiatus settle near adult conspecifics, but likely have to compete with resident adults for access to food. However, field experiments indicate that settlers have access to more resources at occupied sites, and as a result, grow faster despite evidence for competition with residents. This result is a direct consequence of two factors: (1) resident conspecifics facilitate settlers by attracting client fish, and (2) resident conspecifics are strongly associated with high quality habitat. These results highlight the need to simultaneously consider habitat quality and competitive and facilitative interactions between conspecifics when making inferences about ecological processes from spatial patterns of individual performance